​About nQuery
nQuery helps make your clinical trials faster, less costly and more successful. It is an end-to-end platform covering Frequentist, Bayesian, and Adaptive designs with 1000+ sample size procedures. 

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About the webinar

In this free webinar, Ronan Fitzpatrick, Lead Statistician at nQuery, will breakdown statistical power from first principles, how it ties into planning the size of clinical trials and the various approaches available to find the power for a given design.

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Learning objective of this webinar:

In this webinar, Ronan will examine statistical power—the cornerstone of clinical trial design—by breaking it down from foundational principles. You will gain a clear understanding of why power matters, how it influences trial planning, and the strengths/limitations of different power calculation methods.

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Four key areas are covered:

• The Fundamentals of Statistical Power

  • Why power is critical for robust clinical trial design

  • The link between power, Type I/II errors, and sample size

  • Common misconceptions and pitfalls in power analysis

• Power in Trial Planning

  • How power drives decision-making in hypothesis testing

  • Balancing power with practical constraints (budget, timelines, feasibility)

  • Case examples: Underpowered vs. optimally designed trials

• Three Approaches to Power Calculation

  • Approximate Methods

  • Quick, formula-based estimates using normal approximations

  • When to use them—and their limitations

  • Exact Methods

  • Precise power under parametric assumptions (e.g., t-tests, binomial tests)

  • Trade-offs between accuracy and computational complexity

  • Simulation-Based Methods

  • Monte Carlo techniques for complex or non-standard designs

  • Flexibility to model real-world variability and adaptive designs

• Choosing the Right Approach

  • Comparing methods: Accuracy, ease of use, and applicability

  • Practical guidance for selecting the best method for your study

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Duration: 60 minutes
Language of instruction: English

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Statistical Power from First Principles

Today, Thursday, April 3, 2025
8.30pm to 9.30pm IST

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